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Emerging Exosome Treatment Shines Hope on Chronic Kidney Disease and Renal Fibrosis
Chronic Kidney Disease (CKD) is increasingly recognized as a significant health concern worldwide. According to a recent report in The Lancet Regional Health, as of 2022, between 9.1% and 13.4% of the global population suffers from CKD.A promising avenue for treating CKD, particularly in reducing renal fibrosis, involves the use of engineered extracellular
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New Hope for Patients with Hearing Loss: Stem Cell-Derived Exosomes Show Potential for Repairing Cochlear Cells and Nerves
Risk factors for hearing loss include ear infections, prolonged exposure to high-frequency noise, and unhealthy lifestyle habits, which can cause irreversible damage. In daily life, sounds enter the cochlea as vibrations, where they are transformed into auditory signals by hair cells and then transmitted by nerves. Damage to these cochlear hair cells and
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A Breakthrough in Osteoporosis Treatment! Harnessing Exosomes from Skeletal Muscles for Bone Healing
This groundbreaking study shines a light on the exosomes present in these muscle-secreted humoral factors. This compelling evidence underscores the potential of Myo-EVs in facilitating bone repair and restoring bone health, marking a significant stride in osteoporosis treatment.
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Stem Cell Exosomes with Specific miRNAs: A New Frontier in Treating Male Pattern Baldness
As the exploration of exosomes in clinical settings progresses, there's growing anticipation for their integration with existing treatments like Minoxidil and Finasteride. This innovative approach could herald a more comprehensive and effective solution for tackling male pattern baldness, promising a new era of hair loss therapy.
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Exosomes Aid in Repairing Skin Aging Caused by UV Radiation
Overexposure to UV rays stimulates the production of free radicals, leading to wrinkles, spots, and dullness. Therefore, it is essential to use sunscreen and engage in proper skincare to prevent and repair the signs of skin aging.
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Anti-Aging Study: Exosomes Regulate Aging Skeletal Muscle
Extracellular vesicles, including exosomes and microvesicles, are an important medium for intercellular communication, with nearly all cells secreting these vesicles. The research team compared aging muscle stem cells cultured with young serum to those with young serum depleted of extracellular vesicles, observing the impact of extracellular vesicles on activating internal metabolic mechanisms.
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Can Exosomes Also Treat Dry Eye Syndrome?!
Biologically and medically speaking, immune cells activated after transplantation continuously attack hematopoietic tissues and ocular epithelial tissues, including the cornea, conjunctiva, and lacrimal glands, causing widespread inflammation.
Skin Related
- Jarrige, M., et al. The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles. Cells 10(2021).
- An, Y., et al. Exosomes from adipose-derived stem cells and application to skin wound healing. Cell Prolif, e12993 (2021).
- Xiong, M., et al. Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery. Front Cell Dev Biol 8, 574223 (2020).
- Qiu, H., et al. Prospective application of exosomes derived from adipose-derived stem cells in skin wound healing: A review. J Cosmet Dermatol 19, 574-581 (2020).
Hair Related
- Cao, L., et al. Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100. J Nanobiotechnology 19, 20 (2021).
- Yuan, A.R., Bian, Q. & Gao, J.Q. Current advances in stem cell-based therapies for hair regeneration. Eur J Pharmacol 881, 173197 (2020).
- Taghiabadi, E., Nilforoushzadeh, M.A. & Aghdami, N. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods. Skin Pharmacol Physiol 33, 280-292 (2020).
- Nilforoushzadeh, M.A., Aghdami, N. & Taghiabadi, E. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell. Tissue Eng Regen Med 17, 525-536 (2020).
Regenerative Medicine Related
- Watanabe, Y., Tsuchiya, A. & Terai, S. The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future. Clin Mol Hepatol 27, 70-80 (2021).
- Tang, Y., Zhou, Y. & Li, H.J. Advances in mesenchymal stem cell exosomes: a review. Stem Cell Res Ther 12, 71 (2021).
- Shang, F., et al. Advancing application of mesenchymal stem cell-based bone tissue regeneration. Bioact Mater 6, 666-683 (2021).
- Miceli, V., et al. Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine. Int J Mol Sci 22(2021).
Would Healing Related
- Zhu, M., et al. Osteogenically-induced exosomes stimulate osteogenesis of human adipose-derived stem cells. Cell Tissue Bank 22, 77-91 (2021).
- Zhao, B., et al. Human Exosomes Accelerate Cutaneous Wound Healing by Promoting Collagen Synthesis in a Diabetic Mouse Model. Stem Cells Dev 30, 922-933 (2021).
- Zhang, Y., et al. Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis. Mater Sci Eng C Mater Biol Appl 120, 111671 (2021).
- Zhang, Y., et al. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration. Front Cell Dev Biol 9, 685873 (2021).
- Zhang, Y., et al. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-beta receptor inhibition. Stem Cell Res Ther 12, 434 (2021).
Degenerative Arthritis Medical Related
- Qiu, M., Liu, D. & Fu, Q. MiR-129-5p shuttled by human synovial mesenchymal stem cell-derived exosomes relieves IL-1beta induced osteoarthritis via targeting HMGB1. Life Sci 269, 118987 (2021).
- Mustonen, A.M. & Nieminen, P. Extracellular Vesicles and Their Potential Significance in the Pathogenesis and Treatment of Osteoarthritis. Pharmaceuticals (Basel) 14(2021).
- Duan, L., et al. Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis. Curr Med Chem 28, 6458-6483 (2021).
- Bao, C. & He, C. The role and therapeutic potential of MSC-derived exosomes in osteoarthritis. Arch Biochem Biophys 710, 109002 (2021).